Saturday, March 20, 2010

iPost: Motor timing, Parkinsons and cerebellum diseases research study

Yet another study linking role of cerebellum in motor timing and diseases like

Martin Bareš1, 2 Contact Information, Ovidiu V. Lungu3, Ivica Husárová1 and Tomáš Gescheidt1

(1) Department of Neurology, St. Anne's Hospital Medical Faculty Masaryk University Brno, Pekarská 53, 656 91, Brno, Czech Republic
(2) Movement Disorders Centre Brno, Pekarská 53, 656 91, Brno, Czech Republic
(3) Functional Neuroimaging Unit, Geriatric Institute, University of Montreal, Montreal, QC, Canada

Published online: 23 October 2009

There is evidence that both the basal ganglia and the cerebellum play a role in the neural representation of time in a variety of behaviours, but whether one of them is more important is not yet clear. To address this question in the context of predictive motor timing, we tested patients with various movement disorders implicating these two structures in a motor-timing task. Specifically, we investigated four different groups: (1) patients with early Parkinson's disease (PD); (2) patients with sporadic spinocerebellar ataxia (SCA); (3) patients with familial essential tremor (ET); and (4) matched healthy controls. We used a predictive motor-timing task that involved mediated interception of a moving target, and we assessed the effect of movement type (acceleration, deceleration and constant), speed (slow, medium and fast) and angle (0°, 15° and 30°) on performance (hit, early error and late error). The main results showed that PD group and arm ET subgroup did not significantly differ from the control group. SCA and head ET subjects (severe and mild cerebellar damage, respectively) were significantly worse at interception than the other two groups. Our findings support the idea that the basal ganglia play a less significant role in predictive motor timing than the cerebellum. The fact that SCA and ET subjects seemed to have a fundamental problem with predictive motor timing suggests that the cerebellum plays an essential role in integrating incoming visual information with the motor output in a timely manner, and that ET is a heterogeneous entity that deserves increased attention from clinicians.

Keywords  Cerebellum - Essential tremor - Interception - Motor timing - Parkinson's disease - Spinocerebellar ataxia

Contact InformationMartin Bareš
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